Cytochrome P4501A1 Is Required for Vascular Dysfunction and Hypertension Induced by 2,3,7,8-Tetrachlorodibenzo-p-Dioxin

Induction of cytochrome P4501A1 by 2,3,7,8-tetrachlorodibenzo-p-dioxin or indolo(3,2-b)carbazole is associated with oxidative DNA damage.

Induction of cytochrome P4501A1 (CYP1A1) in the hepatoma Hepa1c1c7 cell line results in an elevation in the excretion rate of 8-oxoguanine (oxo8Gua), a biomarker of oxidative DNA damage and the major repair product of 8-oxo-2'-deoxyguanosine (oxo8dG) residues in DNA. Treatment of this cell line with 2,3,7,8-tetrachloro-p-dibenzodioxin (TCDD), a nonmetabolized environmental contaminant, and indo...

2,3,7,8-Tetrachlorodibenzo-p-dioxin.

Identification of the Major Cytochrome P-450 Form Transplacentally Induced in Neonatal Rabbits by 2,3,7,8-Tetrachlorodibenzo-p-dioxin*

Transplacental induction of cytochrome P-450 by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) was studied in newborn rabbit liver. This treatment increased a single cytochrome species in microsomes of newborn rabbit liver as demonstrated by sodium dodecyl sulfatepolyacrylamide gel electrophoresis. This cytochrome species had the same mobility as cytochrome P-450 form 6, isolated from liver microso...

Identification of the major cytochrome P-450 form transplacentally induced in neonatal rabbits by 3,3,7,8-tetrachlorodibenzo-p-dioxin.

Transplacental induction of cytochrome P-450 by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) was studied in newborn rabbit liver. This treatment increased a single cytochrome species in microsomes of newborn rabbit liver as demonstrated by sodium dodecyl sulfatepolyacrylamide gel electrophoresis. This cytochrome species had the same mobility as cytochrome P-450 form 6, isolated from liver microso...

Arsenic inhibits induction of cytochrome P450 1A1 by 2,3,7,8-tetrachlorodibenzo-p-dioxin in human hepatoma cells.

The aim of this study was to examine the arsenic effect on activation of aryl hydrocarbon receptor (AhR)-mediated gene expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD) in human hepatoma cells. The human hepatoma Huh7 cells were treated with sodium arsenite (NaAsO2) from 0.5 to 20 microM for 24 h. Our data revealed that NaAsO2 < or = 10 microM caused no significant cytotoxic effe...